LML134 MedChemExpress (MCE)

Product Name	LML-134
Synonyms	LML134;LML-134;1-Piperazinecarboxylic acid, 4-cyclobutyl-, 1-(1,6-dihydro-1-methyl-6-oxo-3-pyridazinyl)-4-piperidinyl ester
CAS	1542135-76-1
EINECS
Chemical Formula	C19H29N5O3
Molecular Weight	375.47
inchi
Package	1 mg;5 mg;10 mg;25 mg
Price	Email to quote
Descriptions	LML134 LML134 MedChemExpress (MCE) HY-128656 1542135-76-1 99.43% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US Descriptions LML134 LML134 MedChemExpress (MCE) HY-128656 1542135-76-1 99.43% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US may vary elsewhere. LML134 (compound 18b) is an orally active and high selective Histamine 3 receptor (H3R) inverse agonist with Kis of 0.3 nM and 12 nM for hH3R cAMP and hH3R bdg. LML134 penetrates the brain rapidly, leading to high H3R occupancy, and disengages its target with a fast kinetic profile. LML134 has the potential for excessive sleep disorders. LML134 (compound 18b) (oral 10 mg/kg) indicates rapid oral absorption, with a Tmax of 0.5 hours, t1/2 of 1.54 hours and a fraction absorbed of 44%, as well as a rapid clearance in male Sprague-Dawley rats[1]. LML134 (i.v. 1 mg/kg) has t1/2 of 0.44 hours, CL of 28 mL/min/kg and the low plasma protein binding in male Sprague-Dawley rat (Fu =39.0%)[1]. H3 receptor \| \| \| \| \| \| \| \| \| \| [1]. Troxler T, et al. The Discovery of LML134, a Histamine H3 Receptor Inverse Agonist for the Clinical Treatment of Excessive Sleep Disorders. ChemMedChem. 2019 Jul 3 14(13):1238-1247. [Content Brief]
Last Update	2025-04-01 14:45:47

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