GalleinGallein
MedChemExpress (MCE)
HY-D0254
2103-64-2
Pyrogallol phthalein
98.0%
4°C, protect from light *In solvent : -80°C, 6 months
-20°C, 1 month (protect from light)
Room temperature in continental US
may vary elsewhere.
Gallein is a Gβγ subunit signaling inhibitor that can interfere with the interaction between Gβγ subunit and PI3Kγ, regulate platelet function, and exhibit anti-tumor activity[1][3].
Gallein (10 μM, 0-150 h) inhibits β-ionone induced cell invasion in LNCaP prostate cancer cells[1]. Gallein (30 μM, 1 h) increases osteoprotegerin (OPG) synthesis induced by fibroblast growth factor 2 (FGF-2) in osteoblasts[2]. Gallein (25-50 μM, 24 h) inhibits platelet aggregation, secretion, and diffusion functions[3].
Gallein (5 mg/kg, 15 days, i.p.) inhibits tumor cell proliferation in male NSG mice[1]. Gallein (20 mg/kg, b.i.d, i.v.) regulates hemostasis and prevents arterial thrombosis in C57BL/6 mice[3].
Gβγ subunit In Vitro Gallein (10 μM, 0-150 h) inhibits β-ionone induced cell invasion in LNCaP prostate cancer cells[1]. Gallein (30 μM, 1 h) increases osteoprotegerin (OPG) synthesis induced by fibroblast growth factor 2 (FGF-2) in osteoblasts[2]. Gallein (25-50 μM, 24 h) inhibits platelet aggregation, secretion, and diffusion functions[3]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Gallein Related Antibodies Cell Invasion Assay[1]. Cell Line: LNCaP cell
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[1]. Sanz G, et al, Gallein, a Gβγ subunit signalling inhibitor, inhibits metastatic spread of tumour cells expressing OR51E2 and exposed to its odorant ligand. BMC Res Notes. 2017 Oct 30
10(1):541.
[2]. Kuroyanagi G, Hioki T, Matsushima-Nishiwaki R, Kozawa O, Tokuda H. Gallein increases the fibroblast growth factor 2-elicited osteoprotegerin synthesis in osteoblasts. Biochim Biophys Acta Gen Subj. 2024 Aug
1868(8):130635. [Content Brief]
[3]. Alarabi AB, et al. The G-protein βγ subunits regulate platelet function. Life Sci. 2020 Dec 1
262:118481. [Content Brief]