MT 63-78 MedChemExpress (MCE)

Product Name	5-{2',6'-dihydroxy-[1,1'-biphenyl]-4-yl}-1H-indole-3-carbonitrile
Synonyms	MT 63-78;5-[4-(2,6-dihydroxyphenyl)phenyl]-1H-indole-3-carbonitrile;5-{2',6'-dihydroxy-[1,1'-biphenyl]-4-yl}-1H-indole-3-carbonitrile;1H-Indole-3-carbonitrile, 5-(2',6'-dihydroxy[1,1'-biphenyl]-4-yl)-
CAS	1179347-65-9
EINECS
Chemical Formula	C21H14N2O2
Molecular Weight	326.35
inchi
Package	1 mg;5 mg;10 mg
Price	Email to quote
Descriptions	MT 63-78 MT 63-78 MedChemExpress (MCE) HY-W058849 1179347-65-9 98.50% 4°C, protect from light In solvent : -80°C, 6 months Descriptions MT 63-78 MT 63-78 MedChemExpress (MCE) HY-W058849 1179347-65-9 98.50% 4°C, protect from light In solvent : -80°C, 6 months -20°C, 1 month (protect from light) Room temperature in continental US may vary elsewhere. MT 63-78 is a specific and potent direct AMPK activator with an EC50 of 25 μM. MT 63–78 also induces cell mitotic arrest and apoptosis. MT 63-78 blocks prostate cancer growth by inhibiting the lipogenesis and mTORC1 pathways. MT 63-78 has antitumor effects. MT 63-78 (0-50 μM 4 days LNCaP and PC3 cells) treatment shows a dose-dependent decrease in cell number, and concomitant to the activation of AMPK signaling[1]. MT 63-78 (25 μM 24 hours LNCaP and CRPC cells) treatment induces a significant enrichement in the G2/M population[1]. MT 63-78 (0-50 μM 24 hours LNCaP, PC3, C4-4, C4-2B, CL1and 22RV1cells) treatment induces reduction of anti-apoptotic Mcl-1 in concert with accumulation of the pro-apoptotic BH3-only protein Puma[1]. MT 63-78 (0-50 μM 30 minutes LNCaP and PC3 cells) treatment shows a dose-dependent phosphorylation of the two major AMPK targets Acetyl-CoA Carboxylase (ACC) on Ser79 and of Raptor on Ser792. And also increases Thr172 phosphorylation on the AMPK α subunit[1]. MT 63-78 (30 mg/kg intraperitoneal injection daily for 14 days C57 BL/6 male mice) treatment leads to a 33% inhibition of tumor growth[1]. AMPK 25 μM (EC50) mTORC1 \| \| \| \| \| \| \| \| \| \| [1]. Zadra G, et al. A novel direct activator of AMPK inhibits prostate cancer growth by blocking lipogenesis. EMBO Mol Med. 2014 Apr 6(4):519-38. [Content Brief]
Last Update	2025-04-01 14:45:47

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