Gefitinib-based PROTAC 3 MedChemExpress (MCE)

Product Name	Gefitinib-based PROTAC 3
Synonyms	NTN21277;Gefitinib-based PROTAC 3;NTN21277(Gefitinib-based PROTAC 3)
CAS	2230821-27-7
EINECS
Chemical Formula	C47H57ClFN7O8S
Molecular Weight	934.52
inchi
Package	1 mg;5 mg;10 mg;25 mg;50 mg
Price	Get quote
Descriptions	Gefitinib-based PROTAC 3 Gefitinib-based PROTAC 3 MedChemExpress (MCE) HY-123921 2230821-27-7 99.98% 4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months Descriptions Gefitinib-based PROTAC 3 Gefitinib-based PROTAC 3 MedChemExpress (MCE) HY-123921 2230821-27-7 99.98% 4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months -20°C, 1 month (sealed storage, away from moisture and light) Room temperature in continental US may vary elsewhere. Gefitinib-based PROTAC 3, conjugating an EGFR binding element to a von Hippel-Lindau ligand via a linker, induces EGFR degradation with DC50s of 11.7 nM and 22.3 nM in HCC827(exon 19 del) and H3255 (L858R mutantion) cells, respectively. H3255 cells expressing L858R EGFR treated with Gefitinib-based PROTAC 3 (25 nM-10 μM 24 hours), HCC827 cells expressing exon 19 del EGFR treated with Gefitinib-based PROTAC 3 (100 nM-10 μM 24 hours), which enables the degradation of both exon-19 deletion EGFR as well as the mutant isoform containing the L858R activating point mutation, while sparing the WT EGFR[1]. EGFR 11.7 nM (DC50, HCC827(exon 19 del) cells) EGFR 22.3 nM (DC50, H3255 (L858R mutantion) cells) PROTAC \| \| \| \| \| \| \| \| \| \| [1]. Burslem GM, et al. The Advantages of Targeted Protein Degradation Over Inhibition: An RTK Case Study. Cell Chem Biol. 2018 Jan 18 25(1):67-77.e3. [Content Brief]
Supplier Website	https://www.medchemexpress.com/gefitinib-based-protac-3.html
Last Update	2025-05-21 16:50:25

MedChemExpress (MCE) also provides

Thalidomide-4-O-C2-NH2

Category: Signaling Pathways
CAS: 2341840-99-9
Last Update: 2025-05-21 16:50:25

PPARα-MO-1

Category: Signaling Pathways
CAS: 810677-36-2
Last Update: 2025-05-21 16:50:25

Netupitant N-oxide

Category: Signaling Pathways
CAS: 910808-11-6
Last Update: 2025-05-21 16:50:25

MK-0812

Category: Signaling Pathways
CAS: 624733-88-6
Last Update: 2025-05-21 16:50:25

TS-011

Category: Signaling Pathways
CAS: 339071-18-0
Last Update: 2025-05-21 16:50:25

SCH 530348 sulfate

Category: Signaling Pathways
CAS: 705260-08-8
Last Update: 2025-05-21 16:50:25

BAG 956

Category: Signaling Pathways
CAS: 853910-02-8
Last Update: 2025-05-21 16:50:25

YM758

Category: Signaling Pathways
CAS: 312752-85-5
Last Update: 2025-05-21 16:50:25


Supplier Name	MedChemExpress (MCE)
Contact	sales
Tel	609-228-6898
Mobile	609-228-6898
QQ
Email	sales@medchemexpress.com; tech@medchemexpress.com
Website	https://www.medchemexpress.com/
Wechat

Request for quotation

Supplier Contact