Maprotiline MedChemExpress (MCE)

Product Name	Maprotiline
Synonyms	276-Ba MAPROTILINE Maprotyline Maprotiline n-methyl-9,10-ethanoanthracene-9(10h)-propanamine N-Methyl-9,10-ethanoanthracene-9(10H)-propan-1-amine 9,10-Ethano-9,10-dihydro-9-(3-methylaminopropyl)anthracene Synonyms 276-Ba MAPROTILINE Maprotyline Maprotiline n-methyl-9,10-ethanoanthracene-9(10h)-propanamine N-Methyl-9,10-ethanoanthracene-9(10H)-propan-1-amine 9,10-Ethano-9,10-dihydro-9-(3-methylaminopropyl)anthracene 3-(9,10-Dihydro-9,10-ethanoanthracen-9-yl)propylmethylamine
CAS	10262-69-8
EINECS	233-599-4
Chemical Formula	C20H23N
Molecular Weight	277.4
inchi
Package	Inquiry
Price	Get quote
Descriptions	Maprotiline Maprotiline MedChemExpress (MCE) HY-B0444A 10262-69-8 Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US Descriptions Maprotiline Maprotiline MedChemExpress (MCE) HY-B0444A 10262-69-8 Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US may vary elsewhere. Maprotiline is a highly selective noradrenergic reuptake inhibitor that has strong antidepressant, antitumor and neuropathic pain-relieving effects. Maprotiline induces cancer cell apoptosis by targeting the ERK signaling pathway and CRABP1. Maprotiline (0-20 μM, 0-72 h) inhibits the growth of Huh7 and HepG2 cells and induces cell apoptosis[1]. Maprotiline (0-20 μM, 0-72 h) inhibits the metastasis of liver cancer cells[1]. Maprotiline (0-20 μM, 72 h) affects the ERK pathway and inhibits the phosphorylation of SREBP2 in HepG2 and Huh7 cells[1]. Maprotiline targets CRABP1 and regulates cholesterol biosynthesis in HCC cells[1]. Maprotiline (20-40 mg/kg, intraperitoneal injection, twice a week for three weeks) inhibits liver cancer tumor growth in mice[1]. Maprotiline (3-30 mg/kg, intravenous injection, single dose) combined with the synthetic cannabinoid WIN 55,212-2 effectively reduces neuropathic pain in mice[2]. \| \| \| \| \| \| \| \| \| \| [1]. Zheng C, et al. Maprotiline Suppresses Cholesterol Biosynthesis and Hepatocellular Carcinoma Progression Through Direct Targeting of CRABP1. Front Pharmacol. 2021 May 20. 12:689767. [Content Brief] [2]. Gunduz O, et al. Analysis of the anti-allodynic effects of combination of a synthetic cannabinoid and a selective noradrenaline re-uptake inhibitor in nerve injury-induced neuropathic mice. Eur J Pain. 2016 Mar. 20(3):465-71.
Last Update	2025-04-01 14:45:47

MedChemExpress (MCE) also provides

Thalidomide-4-O-C2-NH2

Category: Signaling Pathways
CAS: 2341840-99-9
Last Update: 2025-04-01 14:45:47

PPARα-MO-1

Category: Signaling Pathways
CAS: 810677-36-2
Last Update: 2025-04-01 14:45:47

Netupitant N-oxide

Category: Signaling Pathways
CAS: 910808-11-6
Last Update: 2025-04-01 14:45:47

MK-0812

Category: Signaling Pathways
CAS: 624733-88-6
Last Update: 2025-04-01 14:45:47

TS-011

Category: Signaling Pathways
CAS: 339071-18-0
Last Update: 2025-04-01 14:45:47

SCH 530348 sulfate

Category: Signaling Pathways
CAS: 705260-08-8
Last Update: 2025-04-01 14:45:47

BAG 956

Category: Signaling Pathways
CAS: 853910-02-8
Last Update: 2025-04-01 14:45:47

YM758

Category: Signaling Pathways
CAS: 312752-85-5
Last Update: 2025-04-01 14:45:47


Supplier Name	MedChemExpress (MCE)
Contact	sales
Tel	609-228-6898
Mobile	609-228-6898
QQ
Email	sales@medchemexpress.com; tech@medchemexpress.com
Website	https://www.medchemexpress.com/
Wechat

Request for quotation

Supplier Contact